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Most clients describe minimal discomfort, often less than they expected

Among the GLP-1 RAs and a dual GLP-1/GIP RA, exenatide has the most developed pharmacokinetic model (9 of 30), 61,177184 followed by semaglutide (8 of 30), 68,162,182,185189 liraglutide and dulaglutide (each 5 of 30), 156,177,182,189194 and tirzepatide (3 of 30)

Results from these studies, expected in the coming years, will provide critical evidence regarding the potential neuroprotective effects of GLP-1 therapy

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Although these compounds have demonstrated protective effects under other oxidative stress-related conditions, direct evidence for their application in IDD remains limited